Nanoliposomal systems for rapid diagnosis of thrombi by MRI

Nanoliposomal systems for rapid diagnosis of thrombi by MRI

The research aim of the multidisciplinary project is to develop advanced nanoparticle systems for rapid imaging of thrombi in the cardiovascular system, especially in the brain (cerebral ictus), using in vivo imaging technique MRI. The efficacy of the system will be tested on preclinical rat and rabbit animal models. Contrast agents are based on nanoliposomal labelled with gadolinium complexes for rapid and sensitive imaging with the use of MRI.

The project is connecting specialists in the fields of clinical neurology, biochemistry, pharmacology, nanotechnology, molecular biology, in vivo imaging, physics, mathematics, and mechanical engineering from participating institutions FNUSA-ICRC, Veterinary Research Institute, Institute of Scientific Instruments and also Institute of Biotechnology of the Czech Academy of Sciences. Such multidisciplinary is fairly unique. Therefore, the benefit of realizing this project reaches far beyond accomplishing specific scientific goals because the project will lead to the establishment of multi-institutional and multi-disciplinary platform that will serve as a basis for future research endeavors in the field of modern medicine.

Principal Investigator: prof. MUDr. Robert Mikulík, Ph.D.

Financed by: Czech Health Research Council, AZV16-30299A

Duration: 01.04.2016 – 31.12.2020